アルツハイマーとリウマチ
The hypothesis that AD is caused by mercury from amalgam and the environment is consistent with the theory that AD is an inflammatory disease caused by the body's reaction to an infection or environmental insult.
AD（アルツハイマー）は水銀合金アマルガムおよび環境からの水銀によって引き起こされるという仮説は、ADは感染または環境傷害に対する身体の反応によって引き起こされる炎症性疾患であるという理論と一致する。
The evidence that AD "fits the paradigm of the idiopathic rheumatic disorders" was recently presented by Aisen and Davis.
"According to this model," wrote the authors, "an unknown set of circumstances results in an initial insult triggering an inflammatory reaction in the brain. The inflammation becomes self-propagating, or it continues because the obscure inciting factors persist."
このモデルによれば、未知の一連の状況が脳の炎症反応を誘発する初期の傷害を引き起こす。炎症は自己増殖するか、不明確な刺激因子が残るため継続する。
They argue that the acute phase response may augment production of beta-amyloid, the protein found among the plaques in AD brains.
They conclude that "cytokines, acute phase proteins, activated microglia, and complement," all mechanisms which can be triggered by the acute phase response of the immune system, are "involved" with AD, either as causes or consequences, and that anti-inflammatory drugs may "alter" the progression of AD.They conclude that "cytokines, acute phase proteins, activated microglia, and complement," all mechanisms which can be triggered by the acute phase response of the immune system, are "involved" with AD, either as causes or consequences, and that anti-inflammatory drugs may "alter" the progression of AD.
彼らは、急性期反応が、AD脳の斑の中に見出されるβ-アミロイドの産生を増加させる可能性があると主張している。
Some direct evidence that anti-inflammatory drugs may delay the onset of AD already exists.McGeer et al.reported data suggesting that "the prevalence of Alzheimer disease in patients with rheumatoid arthritis is unexpectedly low and that [the use of] anti-inflammatory therapy might be the explanation."Aisen and Davis cite two other studies that reach the same conclusion.
